Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multi-hierarchical biofunctional polymeric biomaterial to promote wound closure.

Journal of materials science. Materials in medicine·2026

Same author

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Behavioural Characterisation and Pharmacological Validation of an Incisional Wound-Related Pain Model.

European journal of pain (London, England)·2026

Same author

Engineering the Iron Center: Hemin Nanozymes for Programmable Cancer Catalysis.

Nano letters·2026

Same author

MOF-based arginine nanocarriers for coordinated immunometabolic and antitumor modulation in triple negative breast cancer.

Biomaterials science·2026

Same author

A novel chitosan-collagen bilayer scaffold prevents contraction and accelerates cutaneous repair in a rat splint-skin model.

Frontiers in bioengineering and biotechnology·2026

Same journal

Targeting the ischemic cascade: Review on approved and investigational stroke therapies.

Current opinion in pharmacology·2026

Same journal

Senotherapeutic strategies for ovarian aging: Mechanistic insights and translational perspectives.

Current opinion in pharmacology·2026

Same journal

Chrono-immunotherapy in precision oncology: Circadian control of the tumor microenvironment and time-of-day optimization of immune checkpoint blockade.

Current opinion in pharmacology·2026

Same journal

Methotrexate: Integrating molecular pharmacology, systems toxicology, and precision rescue strategies.

Current opinion in pharmacology·2026

Same journal

Acupuncture and non-invasive neuromodulation-induced neuro-endocrine-immune changes associated with the amelioration of depression-like behaviors: A systematic review of animal studies.

Current opinion in pharmacology·2026

Same journal

Alopecia areata: Mechanisms, targeted therapies, and translational challenges.

Current opinion in pharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

Engineered systems for therapeutic angiogenesis.

Shane Browne¹, Abhay Pandit¹

¹Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Ireland.

Current Opinion in Pharmacology

|August 15, 2017

Summary

This summary is machine-generated.

Therapeutic angiogenesis aims to treat ischemic disease by enhancing blood supply. Biomaterial-based delivery systems are advancing safe and effective angiogenic therapies for clinical translation.

More Related Videos

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Published on: September 18, 2019

Related Experiment Videos

Last Updated: Feb 24, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Published on: September 18, 2019

Area of Science:

Biomedical Engineering
Regenerative Medicine
Vascular Biology

Background:

Ischemic disease results from inadequate blood supply, causing tissue damage.
Therapeutic angiogenesis offers potential treatment by improving tissue perfusion.
Current pro-angiogenic therapies face clinical translation challenges due to efficacy and safety concerns.

Purpose of the Study:

To review the progress in developing biomaterial-based delivery systems for angiogenic therapies.
To highlight advancements in overcoming clinical translation hurdles for angiogenesis treatments.
To discuss the potential of controlled delivery systems for safe and effective vascularization.

Main Methods:

Review of current literature on biomaterials for angiogenic factor delivery.
Analysis of strategies for controlled release of therapeutic agents.
Evaluation of translatable systems for inducing angiogenesis.

Main Results:

Significant progress in designing biomaterial systems for angiogenic factor delivery.
Development of methods to control the release kinetics of pro-angiogenic agents.
Identification of promising approaches for safe and effective therapeutic angiogenesis.

Conclusions:

Biomaterial-based delivery systems are crucial for advancing therapeutic angiogenesis.
Controlled delivery is key to overcoming efficacy and safety issues in clinical translation.
Continued development in biomaterials promises effective treatments for ischemic diseases.