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Targeted nanoparticles show promise for biomedical applications, but protein corona formation can affect their behavior. Strategies exist to exploit this corona for improved nanoparticle targeting and efficacy.

Keywords:
active targetingcarrier designdrug deliverynanoparticlesprotein corona

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Nanoengineered particles are increasingly used in biomedical applications like diagnosis, imaging, and therapy.
  • Targeted particles functionalized with ligands can accumulate at specific sites, enhancing efficacy and reducing side effects.
  • However, the biological environment can alter particle properties through biomolecule adsorption and protein corona formation, leading to unpredictable behavior.

Purpose of the Study:

  • To review parameters influencing the targeting ability of particulate drug carriers.
  • To emphasize the impact of the protein corona on nanoparticle targeting.
  • To highlight strategies for leveraging the protein corona to enhance particle targeting.

Main Methods:

  • Literature review focusing on nanoparticle targeting and protein corona effects.
  • Analysis of factors affecting nanoparticle behavior in biological environments.
  • Discussion of strategies for exploiting protein corona for improved targeting.

Main Results:

  • The protein corona significantly impacts the physicochemical properties and biological fate of targeted nanoparticles.
  • Understanding protein corona formation is crucial for designing effective targeted delivery systems.
  • Exploiting the protein corona offers a promising avenue for enhancing nanoparticle targeting efficiency.

Conclusions:

  • Consideration of biological environment effects, particularly the protein corona, is essential during early particle design.
  • Strategies to exploit the protein corona can improve nanoparticle targeting and therapeutic outcomes.
  • Integrating advanced techniques like 3D models and flow-based technologies will accelerate the development of targeted nanoparticles.