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Updated: Feb 24, 2026

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The Development of Novel Near-Infrared (NIR) Tetraarylazadipyrromethene Fluorescent Dyes
Sung-Chan Lee1, Duanting Zhai2, Parag Mukherjee3
1Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Biopolis, 138667, Singapore. lee_sung_chan@sbic.a-star.edu.sg.
Abstract:
Novel structures of an near-infrared (NIR) tetraarylazadipyrromethene (aza-BODIPY) series have been prepared. We designed the core structure containing two amido groups at the para-position of the aromatic rings. The amido group was incorporated to secure insensitivity to pH and to ensure a bathochromic shift to the NIR region. Forty members of aza-BODIPY compounds were synthesized by substitution of the acetyl group with commercial amines on the alpha bromide. The physicochemical properties and photostability were investigated and the fluorescence emission maxima (745~755 nm) were found to be in the near infrared (NIR) range of fluorescence.
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