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Pneumatosis intestinalis in an SIV-infected rhesus macaque (Macaca mulatta)

A L Johnson1,2, K Van Rompay1, J R Reader1

  • 1California National Primate Research Center, Anatomic and Clinical Pathology Service, University of California, Davis, CA, USA.

Journal of Medical Primatology
|August 16, 2017
PubMed

Insights

Pneumatosis intestinalis (PI) was observed in a simian immunodeficiency virus (SIV)-infected rhesus macaque. This finding suggests PI may occur in SIV-infected non-human primates, similar to human immunodeficiency virus (HIV) cases.

Area of Science:

  • Veterinary Pathology
  • Primate Virology
  • Gastrointestinal Diseases

Background:

  • Pneumatosis intestinalis (PI) is a rare condition characterized by gas in the intestinal wall.
  • PI is often an incidental finding in domestic animals and humans.
  • PI has been associated with various comorbidities, including human immunodeficiency virus (HIV) infection.

Observation:

  • This report details emphysematous changes consistent with PI.
  • The observation was made in a rhesus macaque (Macaca mulatta).
  • The rhesus macaque was infected with simian immunodeficiency virus (SIV).

Findings:

  • This case presents emphysematous changes indicative of PI in an SIV-infected non-human primate.
  • This finding expands the known associations of PI to SIV infection in macaques.

Implications:

  • The study suggests a potential link between SIV infection and PI in non-human primates.
  • This finding may inform veterinary diagnostics and research into gastrointestinal manifestations of lentiviral infections.
  • Further research is warranted to understand the pathogenesis and clinical significance of PI in SIV-infected macaques.
Keywords:
intestinal emphysemanon-human primatepneumatosis cystoides intestinalis

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