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Mixed Malignant Pancreatic Tumour in a Rhesus Macaque (Macaca mullata).
K J Olstad1, T Kasantikul2, M Kiupel2
1California National Primate Research Center, University of California Davis, Davis, California, USA.
Journal of Comparative Pathology
|March 23, 2019
Summary
A rare mixed acinar-neuroendocrine carcinoma was identified in a rhesus macaque. This malignant pancreatic tumor involved both exocrine and endocrine cells, highlighting a unique case in non-human primates.
Area of Science:
- Veterinary Pathology
- Primate Oncology
- Comparative Medicine
Background:
- Pancreatic islet cell tumors are infrequent in non-human primates.
- Most reported cases in rhesus macaques (Macaca mullata) are benign islet cell adenomas.
Observation:
- A pancreatic tumor composed of both exocrine and endocrine cells was identified in a captive rhesus macaque.
- This tumor exhibited characteristics of a mixed acinar-neuroendocrine carcinoma.
Findings:
- Immunohistochemistry confirmed neoplastic changes in both exocrine and endocrine components.
- The tumor showed cellular atypia, invasion, and metastasis, consistent with malignancy.
- Hormone expression (gastrin, insulin, pancreatic polypeptide, somatostatin, glucagon) varied within the neoplastic cells.
Implications:
- This case expands the understanding of pancreatic neoplasms in non-human primates.
- Accurate diagnosis is crucial to differentiate mixed tumors from other pancreatic carcinomas.
- Provides insights into comparative oncology and primate health.
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