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The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the

Mikkel Østergaard1,2, Charles G Peterfy3,4, Paul Bird3,4

  • 1From the Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen; Slagelse Hospital, Slagelse, Denmark; Spire Sciences Inc., Boca Raton, Florida; Medicine and Orthopedics, University of California; Synarc Inc., San Francisco, California, USA; University of New South Wales (NSW), Sydney, Australia; Hôpital Pitié-Salpétrière, APHP, Université Paris VI, Paris, France; Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. mo@dadlnet.dk.

The Journal of Rheumatology
|August 17, 2017
PubMed
Abstract

Insights

Updated recommendations for the Rheumatoid Arthritis Magnetic Resonance Imaging (RAMRIS) scoring system are provided. These advances enhance MRI

Area of Science:

  • Rheumatology
  • Medical Imaging
  • Clinical Trials

Background:

  • The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS) has been the standard for objectively quantifying RA inflammation and damage since 2002.
  • It evaluates bone erosion, bone marrow edema/osteitis, and synovitis.

Purpose of the Study:

  • To identify advances in RA MRI since 2002.
  • To provide updated recommendations for the RAMRIS scoring system based on these advances.

Main Methods:

  • Analysis of MRI studies and technical/scientific advancements relevant to RAMRIS by the OMERACT MRI in Arthritis Working Group.
  • Development of updated considerations for image acquisition, RAMRIS definitions, and scoring systems for existing and new RA pathologies.
  • Outlining a research agenda.

Main Results:

  • RAMRIS variables demonstrate face, construct, and criterion validity, high reliability, and sensitivity to change.
  • RAMRIS enables demonstration of inhibited structural damage progression more efficiently than conventional radiography.
  • Technical improvements facilitate validation of scoring methods for new pathologies like joint space narrowing and tenosynovitis, which can be added to RAMRIS.
  • Combined scores may enhance sensitivity to change and discriminative power, requiring further research.

Conclusions:

  • Updated 2016 RAMRIS recommendations were developed.
  • A research agenda for future RA MRI studies was outlined.
Keywords:
MAGNETIC RESONANCE IMAGINGOMERACTOUTCOME ASSESSMENTRHEUMATOID ARTHRITIS

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