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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Lead as a Risk Factor for Osteoporosis in Post-menopausal Women.

Anjali Manocha1, L M Srivastava1, Seema Bhargava1

  • 1Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.

Indian Journal of Clinical Biochemistry : IJCB
|August 17, 2017
PubMed
Summary
This summary is machine-generated.

Postmenopausal women face higher lead exposure risks due to bone lead release during menopause. Reducing bone resorption can decrease this endogenous lead exposure and improve women's health.

Keywords:
LeadOsteoporosisPost-menopausalRisk

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Area of Science:

  • Environmental Health
  • Bone Metabolism
  • Women's Health

Background:

  • Lead exposure is a significant risk factor for osteoporosis.
  • 80-90% of absorbed lead accumulates in adult bones.
  • Bone lead is released into the bloodstream during enhanced bone resorption, such as during menopause.

Purpose of the Study:

  • To highlight the increased risk of endogenous lead exposure in postmenopausal women.
  • To explore the link between estrogen deficiency, bone resorption, and lead release.
  • To identify factors influencing bone and blood lead levels in women.

Main Methods:

  • Review of existing literature on lead exposure and bone metabolism.
  • Analysis of hormonal and age-related changes in postmenopausal bone metabolism.
  • Identification of coexisting variates affecting bone and blood lead levels.

Main Results:

  • Postmenopausal women are at higher risk for bone lead release due to estrogen deficiency and increased osteoclast activity.
  • High blood lead levels exacerbate lead-related adverse outcomes, including hypertension, kidney dysfunction, cognitive decline, and cardiovascular mortality.
  • Factors like ethnicity, occupation, residence, education, smoking, and alcohol use significantly influence bone and blood lead levels.

Conclusions:

  • Interventions to reduce bone resorption during menopause can decrease endogenous lead exposure.
  • Reducing bone lead release is crucial for mitigating menopause-associated morbidity and mortality.
  • Identifying modifiable factors can prevent bone lead release, reduce chronic lead exposure, and improve postmenopausal women's health outcomes.