Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.9K
Cancer Prevention02:59

Cancer Prevention

8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

31
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
31
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Effect of preexisting human leukocyte antigen donor-specific antibodies especially human leukocyte antigen-DQ on kidney transplant outcome.

Frontiers in nephrology·2026
Same author

ConLymphNet: A Generalizable Region-Constrained Deep Learning Architecture for Precise Abdominal Lymph Node Segmentation Across Cancer Types.

JCO clinical cancer informatics·2026
Same author

The Construction and Evaluation of a Pediatric Emergency Medicine Bootcamp for Graduating Emergency Medicine Residents.

AEM education and training·2026
Same author

Artificial Intelligence for Molecular Subtyping in Unresectable Gallbladder Cancer: A Proof-of-Concept Study for CT-based HER2 Status Prediction.

Journal of clinical and experimental hepatology·2026
Same author

Efficacy and safety of peptide receptor radionuclide therapy in advanced foregut and hindgut neuroendocrine tumors: a real-world experience from a single institution.

Annals of nuclear medicine·2026
Same author

Simple Interventions Can Improve Access to Autologous Stem Cell Transplant in Low- and Lower-Middle-Income Countries by Reducing Complexity, Lowering Costs, and Minimizing Infectious Risks.

Pediatric blood & cancer·2026

Related Experiment Video

Updated: Feb 24, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K

Genetic Variation in CD166 Gene and Its Association with Bladder Cancer Risk in North Indian Population.

Archana Verma1, Rakesh Kapoor1, Rama Devi Mittal1

  • 1Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014 India.

Indian Journal of Clinical Biochemistry : IJCB
|August 17, 2017
PubMed
Summary

Genetic variations in the CD166 gene influence bladder cancer risk. Specific CD166 SNPs (rs6437585 and rs10511244) are linked to reduced bladder cancer risk, while CD166 rs1157 is associated with increased risk in North Indians.

Keywords:
BCG immunotherapyBladder cancerCD166 gene (ALCAM)PCR–RFLP

More Related Videos

Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.4K
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.2K

Related Experiment Videos

Last Updated: Feb 24, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Cell-Free DNA Integrity Analysis in Urine Samples
07:58

Cell-Free DNA Integrity Analysis in Urine Samples

Published on: January 5, 2017

14.4K
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

13.2K

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Adhesion molecules are crucial in cancer development.
  • Genetic variations (polymorphisms) in these molecules can affect cancer susceptibility.
  • The CD166 gene, encoding an adhesion molecule, is a potential factor in bladder cancer.

Purpose of the Study:

  • To investigate the association between three single nucleotide polymorphisms (SNPs) in the CD166 gene and bladder cancer risk.
  • To evaluate CD166 rs6437585 C/T, CD166 rs10511244 C/T, and CD166 rs1157 A/G in a North Indian population.

Main Methods:

  • Genotyping of 270 healthy controls and 240 bladder cancer patients.
  • Taqman allelic discrimination assay for CD166 rs6437585 C/T and CD166 rs10511244 C/T.
  • PCR-RFLP for CD166 rs1157 A/G.
  • Statistical analysis using SPSS and haplotypic analysis with SNP analyzer.

Main Results:

  • CD166 rs6437585 C/T and CD166 rs10511244 C/T were associated with a significantly reduced risk of bladder cancer.
  • CD166 rs1157 A/G showed a significant association with an increased risk of bladder cancer at both genotypic and allelic levels.
  • Haplotypic analysis identified specific combinations (CCG, CTA, TCG) with altered bladder cancer risk.

Conclusions:

  • CD166 rs6437585 C/T and CD166 rs10511244 C/T may serve as protective markers against bladder cancer in North Indians.
  • CD166 rs1157 A/G could be a potential marker for bladder cancer risk prediction in this population.
  • No significant associations were found when stratifying by smoking, tumor grade/stage, or BCG therapy.