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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.

Yangchun Xie1, Shan Zhu2, Xinxin Song3

  • 1The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Protein Modification and Degradation Laboratory, Guangzhou Medical University, Guangzhou, Guangdong 510510, China; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Cell Reports
|August 17, 2017
PubMed
Summary

The tumor suppressor p53 (TP53) limits ferroptosis by inhibiting dipeptidyl-peptidase-4 (DPP4) activity. Loss of TP53 promotes lipid peroxidation and cell death, offering a potential strategy for colorectal cancer treatment.

Keywords:
ACSL4NOXNRF2SLC7A11TP53ddp4ferroptosisironlipid peroxidationprecision medicine

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