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P2Y2 Receptor Functions in Cancer: A Perspective in the Context of Colorectal Cancer

Fernand-Pierre Gendron1, Morgane Placet2, Guillaume Arguin2

  • 1Department of Anatomy and Cell Biology, Faculté de Médecine et des Sciences de la Santé, Pavillon de Recherche Appliquée sur le Cancer, Université de Sherbrooke, Sherbrooke, QC, Canada. fernand-p.gendron@ushebrooke.ca.

Advances in Experimental Medicine and Biology
|August 18, 2017
PubMed

Insights

Purinergic signaling, involving adenosine triphosphate and P2Y2 receptors, influences cancer cell behavior. Targeting the P2Y2 receptor shows potential for treating colorectal cancer and overcoming drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Purinergic signaling regulates cancer cell functions.
  • Extracellular adenosine 5' triphosphate (ATP) activates P2 nucleotide receptors.
  • The P2Y2 receptor is implicated in cancer cell coordination.

Purpose of the Study:

  • To examine the P2Y2 receptor's role in cancer.
  • To establish the P2Y2 receptor as a therapeutic target for colorectal cancer.
  • To elucidate the P2Y2 receptor's function in cancer progression and drug resistance.

Main Methods:

  • Literature review on purinergic signaling and P2Y2 receptor.
  • Analysis of P2Y2 receptor's impact on cancer cell proliferation, survival, and dissemination.
  • Investigation of P2Y2 receptor's role in drug resistance.

Main Results:

  • The P2Y2 receptor modulates cancer cell proliferation and survival.
  • P2Y2 receptor signaling promotes cancer cell dissemination and metastasis formation.
  • The P2Y2 receptor contributes to the development of cancer drug resistance.

Conclusions:

  • The P2Y2 receptor is a key regulator of cancer cell behavior.
  • Targeting the P2Y2 receptor is a promising strategy for colorectal cancer treatment.
  • Understanding P2Y2 receptor function is crucial for overcoming therapeutic challenges in cancer.
Keywords:
CancerColorectal cancerExtracellular nucleotidesP2Y2 receptor

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