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Related Experiment Video

Updated: Feb 24, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Changes to white matter microstructure in transient ischemic attack: A longitudinal diffusion tensor imaging study.

Jennifer K Ferris¹, Jodi D Edwards^2,3, Jennifer A Ma¹

¹Brain Behaviour Laboratory, University of British Columbia, Vancouver, British Columbia, Canada.

Human Brain Mapping

|August 18, 2017

Summary

This summary is machine-generated.

Transient ischemic attack (TIA) causes diffuse white matter changes, particularly in sensorimotor tracts. These microstructural alterations in fractional anisotropy (FA) persist long after TIA symptoms resolve, indicating lasting brain damage.

Keywords:

DTI FA MRI TBSS TIA

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Last Updated: Feb 24, 2026

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Area of Science:

Neuroimaging
Neurology
White Matter Microstructure

Background:

Transient ischemic attack (TIA) is known to cause localized ischemic changes.
Previous research has not investigated diffuse white matter microstructural changes or longitudinal changes following TIA.

Purpose of the Study:

To examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms.
To track these microstructural changes longitudinally over 90 days.

Main Methods:

Diffusion MRI was used to acquire data from 20 individuals with recent TIA and 12 healthy controls.
Track-based spatial statistics (TBSS) analyzed voxel-wise FA differences at baseline and 90 days post-TIA.

Main Results:

Individuals with TIA showed significantly lower FA in anterior white matter tracts compared to controls.
Affected tracts included forceps minor, anterior thalamic radiations, cingulum, inferior fronto-occipital fasciculus, and corticospinal tract.
No longitudinal changes were observed in most affected tracts, though anterior thalamic radiations showed normalization over 90 days.

Conclusions:

TIA with sensorimotor symptoms is associated with decreased FA in critical sensorimotor white matter tracts.
These microstructural changes persist beyond clinical symptom resolution, suggesting more profound brain damage than previously understood.
Diffusion tensor imaging (DTI) shows potential as a marker for TIA-associated white matter pathway alterations.