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MANAGEMENT OF RETINOBLASTOMA WITH HIV SEROPOSITIVITY

Abhinav Dhami1, Anita Ramesh2, Vikas Khetan1

  • 1Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, India; and.

Retinal Cases & Brief Reports
|August 18, 2017
PubMed

Insights

This case report details the management of a child with retinoblastoma and HIV. It highlights the complex treatment decisions for co-occurring retinoblastoma and HIV.

Area of Science:

  • Pediatric Oncology
  • Ophthalmology
  • Infectious Diseases

Background:

  • Retinoblastoma is the most common primary intraocular malignancy in children.
  • Human Immunodeficiency Virus (HIV) infection affects multiple organ systems, including the eyes.
  • The co-occurrence of retinoblastoma and HIV is exceptionally rare, with limited documented cases.

Observation:

  • A 3-year-old male presented with bilateral retinoblastoma (Group B, right eye; Group E, left eye).
  • The child tested positive for HIV-1 antibodies; parents were also HIV-positive.
  • Management involved focal laser therapy for the right eye and systemic chemotherapy, with enucleation planned for the left eye.

Findings:

  • The case presents a unique clinical scenario of retinoblastoma coexisting with HIV.
  • Treatment involved a combination of local therapy, systemic chemotherapy, and planned enucleation.
  • Parents received referral for antiretroviral therapy.

Implications:

  • This case raises critical questions regarding the combined management of retinoblastoma and HIV, particularly the use of systemic chemotherapy alongside antiretroviral therapy.
  • Further research and case reports are needed to establish optimal treatment protocols for this rare co-occurrence.
  • Understanding potential drug interactions and treatment efficacy in co-infected patients is crucial for future management strategies.
Abstract

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