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Updated: Feb 24, 2026
Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
Published on: October 18, 2015
A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation
Olivier Thoumine1, Pascale Marchot2
1Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la Recherche Scientifique, University of Bordeaux, 33000 Bordeaux, France.
Abstract:
Neurexins and neuroligins form trans-synaptic complexes that promote synapse development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al., 2017) complement and strengthen two recent reports by the Kim and Rudenko teams (Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by which MDGAs challenge the neurexin-neuroligin partnership.
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