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Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

Developmental Dysfunction of VIP Interneurons Impairs Cortical Circuits.

Renata Batista-Brito¹, Martin Vinck², Katie A Ferguson¹

¹Yale University School of Medicine, Department of Neuroscience, 333 Cedar St., New Haven, CT, 06520, USA; Kavli Institute of Neuroscience, Yale University, 333 Cedar St., New Haven CT, 06520, USA.

|August 18, 2017

Summary

Vasoactive intestinal peptide (VIP) interneurons are crucial for developing brain circuits. Removing their receptor ERBB4 impairs sensory processing and learning, highlighting VIP interneurons' role in neurodevelopment.

Keywords:

ErbB4 GABAergic VIP cholinergic cortex development gCAMP6 interneuron somatostatin visual

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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Area of Science:

Neuroscience
Developmental Biology
Cellular Neuroscience

Background:

GABAergic interneurons are vital for cortical circuit development, but their diverse roles are not fully understood.
Neuregulin 1 (NRG1) and its receptor ERBB4 are essential for interneuron maturation.

Purpose of the Study:

To investigate the role of vasoactive intestinal peptide (VIP)-expressing interneurons in postnatal cortical circuit maturation.
To determine the impact of ERBB4 deletion in VIP interneurons on cortical function and sensory learning.

Main Methods:

Conditional deletion of the ErbB4 receptor specifically in VIP interneurons during development.
In vivo analysis of cortical circuit activity, temporal organization, and state dependence.
Assessment of sensory responses and learning in mature animals lacking ErbB4 in VIP interneurons.

Main Results:

ErbB4 removal from VIP interneurons altered their activity and disrupted cortical temporal organization and state dependence.
These deficits emerged during adolescence and persisted into adulthood.
Animals lacking ErbB4 in VIP interneurons showed reduced sensory responses and impaired sensory learning.

Conclusions:

VIP interneurons play a critical role in the postnatal development of cortical circuits.
Dysfunction of VIP interneurons, potentially linked to ERBB4 signaling, may contribute to neurodevelopmental disorders.
Understanding GABAergic interneuron diversity offers new insights into cortical development and associated pathologies.