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Related Concept Videos

Brain Imaging01:14

Brain Imaging

787
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
787
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
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Immune Modulation Therapy and Imaging: Workshop Report.

Anthony F Shields1,2, Paula M Jacobs2, Mario Sznol3

  • 1Karmanos Cancer Institute, Wayne State University, Detroit, Michigan shieldsa@karmanos.org.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 19, 2017
PubMed
Summary
This summary is machine-generated.

Imaging plays a crucial role in assessing cancer immunotherapy responses. New imaging techniques are being developed to overcome challenges like pseudoprogression and accurately measure treatment effectiveness.

Keywords:
biomarkersimaging cancerimmunotherapy

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Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Immunotherapy offers promising cancer treatment with prolonged responses.
  • Evaluating immunotherapy effectiveness is challenging due to variable and delayed responses.
  • Early imaging may incorrectly suggest tumor progression (pseudoprogression), complicating treatment decisions.

Purpose of the Study:

  • To review the current state and future directions of imaging in assessing cancer immunotherapy.
  • To highlight the need for improved imaging methods to evaluate treatment response and guide patient management.

Main Methods:

  • Discussion of current imaging modalities (CT, MRI, 18F-FDG PET) and their limitations.
  • Exploration of emerging imaging technologies, including radiomics and novel radiotracers.
  • Focus on imaging the tumor microenvironment and immune status.

Main Results:

  • Current imaging methods can be confounded by pseudoprogression.
  • Advanced imaging techniques (radiomics, PET, MRI) show potential for better response assessment.
  • Development of targeted imaging agents (small molecules, antibodies) to visualize immune activity.

Conclusions:

  • Improved imaging is essential for accurate assessment of immunotherapy response.
  • Validation of new imaging biomarkers in clinical trials is critical.
  • Integrating imaging data with clinical outcomes will drive the development of better assessment tools.