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Active prosthesis dependent functional cortical reorganization following stroke.

Christian Merkel¹, Janet Hausmann², Jens-Max Hopf^2,3

¹Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany. christian.merkel@med.ovgu.de.

Scientific Reports

|August 19, 2017

Summary

Active prostheses improve gait in stroke patients with drop-foot by inducing brain plasticity. Larger changes in the lesioned hemisphere led to sustained gait improvements, even without the device.

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Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Area of Science:

Neuroscience
Rehabilitation Medicine
Biomedical Engineering

Background:

Stroke often causes drop-foot, impairing gait.
Active prostheses offer a potential solution for gait restoration.

Purpose of the Study:

To investigate the neural mechanisms underlying gait improvement from active prostheses in chronic stroke patients.
To correlate brain plasticity with gait performance changes.

Main Methods:

Magnetoencephalography (MEG) and somatosensory stimulation were used.
Gait analyses were performed before and after prosthesis implantation.
Eleven chronic stroke patients with drop-foot participated.

Main Results:

All patients showed improved gait with the active prosthesis.
Significant sensorimotor cortex plasticity was observed.
Greater ipsilesional plasticity correlated with sustained gait improvement when the prosthesis was off.

Conclusions:

Active prostheses induce beneficial neuroplasticity for gait recovery in stroke survivors.
The degree and location of brain plasticity influence the long-term effectiveness of the prosthesis.
Findings inform prosthesis selection and patient evaluation for optimal rehabilitation outcomes.