Related Experiment Video

Updated: Feb 24, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

24.0K

Aspergillus Bronchitis in Patients with Cystic Fibrosis

Claudia Brandt1, Jobst Roehmel1, Volker Rickerts2

  • 1Department of Pediatric Pneumology and Immunology, Cystic Fibrosis Center, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Mycopathologia
|August 19, 2017
PubMed

Insights

Aspergillus fumigatus colonization affects over 30% of cystic fibrosis patients. Antifungal treatment for Aspergillus bronchitis in CF patients can significantly reduce respiratory symptoms and improve lung function.

Area of Science:

  • Medical Mycology
  • Pulmonology
  • Infectious Diseases

Background:

  • Aspergillus fumigatus is a common airway colonizer in cystic fibrosis (CF) patients.
  • This colonization can lead to severe respiratory infections, including bronchitis.

Purpose of the Study:

  • To analyze the epidemiology of Aspergillus in CF patients.
  • To describe the clinical characteristics and treatment outcomes of Aspergillus bronchitis in CF.
  • To investigate diagnostic markers for Aspergillus bronchitis.

Main Methods:

  • Analysis of the German Cystic Fibrosis Registry (n=2599) for colonization rates.
  • Retrospective analysis of 10 treated cases of Aspergillus bronchitis.
  • Prospective cohort study (n=22) evaluating serological, molecular, and microbiological markers.

Main Results:

  • Aspergillus colonization rate in CF patients is 32.5%.
  • Retrospective analysis showed antifungal treatment improved cough, sputum production, and lung function.
  • Prevalence of Aspergillus bronchitis was estimated at 1.6% (retrospective) and 9% (prospective).

Conclusions:

  • Aspergillus bronchitis occurs in a subset of colonized CF patients.
  • Antifungal therapy is effective in alleviating symptoms and improving lung function in CF patients with Aspergillus bronchitis.
Keywords:
Aspergillus fumigatusBronchitisColonizationCystic FibrosisPneumonia

More Related Videos

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives10:26

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

11.8K
Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients07:25

Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients

Published on: July 16, 2020

3.6K

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
944
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
580
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
907
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.7K
Chest Physiotherapy01:24

Chest Physiotherapy

Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
2.1K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K