Related Experiment Videos
Microcephaly Caused by Lymphocytic Choriomeningitis Virus
Emerging Infectious Diseases
|August 19, 2017
Summary
Congenital microcephaly can result from fetal lymphocytic choriomeningitis virus (LCMV) infection. Diagnosis involves prenatal ultrasound and amniotic fluid PCR confirmation of LCMV.
Area of Science:
- Medical Virology
- Prenatal Diagnostics
- Fetal Medicine
Background:
- Congenital infections pose significant risks to fetal development.
- Lymphocytic choriomeningitis virus (LCMV) is an underrecognized teratogenic agent.
- Early diagnosis of fetal infections is crucial for management.
Observation:
- A 29-year-old pregnant woman presented with concerns at 23 weeks' gestation.
- Prenatal ultrasonography revealed microcephaly in the fetus.
- Differential diagnosis excluded other common infectious agents.
Findings:
- Amniotic fluid sample tested positive for lymphocytic choriomeningitis virus via PCR.
- This confirmed fetal LCMV infection as the cause of microcephaly.
- The diagnosis was supported by negative results for other potential teratogens.
Implications:
- Highlights the importance of considering LCMV in congenital microcephaly cases.
- Suggests the need for improved awareness and diagnostic protocols for LCMV in pregnancy.
- Underscores the potential for severe neurological sequelae from in utero viral infections.