Modified bacterial cellulose based self-healable polyeloctrolyte film for wound dressing application

Area of Science:

• Materials Science
• Biomaterials Engineering
• Nanotechnology

Background:

• Chitosan (Cts) and bacterial cellulose (BC) are biocompatible polymers with potential in advanced materials.
• Developing self-healing materials is crucial for extending product lifespan and reducing waste.
• Sustainable and green sources for nanomaterials are increasingly sought after in various industries.

Purpose of the Study:

• To prepare a self-healable polyelectrolyte film using chitosan and modified bacterial cellulose.
• To investigate the dynamic self-healing properties of the composite film at physiological pH.
• To evaluate the potential of the film for drug delivery, specifically curcumin, for wound healing applications.

Main Methods:

• Anionic modification of bacterial cellulose (BC) using poly(acrylic acid) via a "grafting from" technique.
• Crosslinking of cationically charged chitosan (Cts) with anionically modified BC to form a polyelectrolyte film.
• Assessment of self-healing capability by observing notch disappearance in a physiological pH buffer.
• Cytotoxicity evaluation using XTT assay and drug delivery studies with curcumin.

Main Results:

• The composite film exhibited dynamic self-healing properties, with notches disappearing through diffusion and ionic interlocking at physiological pH.
• The XTT assay confirmed the non-toxic nature of the composite film.
• The film successfully delivered curcumin, a hydrophobic drug known for antimicrobial and wound healing properties.

Conclusions:

• A novel self-healable polyelectrolyte film based on chitosan and anionic bacterial cellulose was successfully developed.
• The film demonstrates efficient dynamic self-healing via ionic interactions at physiological conditions.
• The material shows promise as a non-toxic platform for delivering therapeutic agents like curcumin for wound care.