Related Experiment Video
Updated: Feb 24, 2026

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
[Rhinovirus: Underestimated pathogens in patients during the neonatal period].
S Zacharie1, A Vabret2, B Guillois3
1Service de pédiatrie médicale, CHU de Caen, avenue Côte-de-Nacre, 14033 Caen, France; Service de pédiatrie, hôpital Sainte-Musse, centre hospitalier intercommunal Toulon-La-Seyne-sur-Mer, CS 31412, 83056 Toulon, France.
Rhinoviruses and enteroviruses (E/RV) cause significant illness in hospitalized neonates, with nosocomial transmission being a concern. Testing for these viruses in neonates with unexplained symptoms can improve diagnosis and reduce unnecessary antibiotic use.
Area of Science:
- Neonatal Medicine
- Virology
- Infectious Diseases
Background:
- Rhinoviruses and enteroviruses (E/RV) are frequently detected in children with airway issues.
- Epidemiological data on E/RV morbidity in neonates is lacking.
- Advancements in virological tools facilitate easier detection of E/RV.
Purpose of the Study:
- To determine the incidence of E/RV infections in hospitalized neonates.
- To characterize the clinical presentation of E/RV infections in this population.
Main Methods:
- Retrospective analysis of virology specimens from neonates hospitalized between 2006 and 2011.
- Review of clinical data from patient charts.
Main Results:
- E/RV was identified in 1.9% of hospitalized neonates (87 patients).
- Common symptoms included drowsiness, fever, respiratory distress, and poor feeding.
- Nosocomial acquisition was suspected in 50% of E/RV infections within the neonatal department.
Conclusions:
- E/RV infections contribute significantly to neonatal morbidity.
- Nosocomial transmission of E/RV in neonates is likely underestimated.
- Testing for E/RV in neonates with unexplained symptoms is recommended to guide treatment and reduce antibiotic use.
Related Concept Videos
Pneumonia II: Pathophysiology
Rh Blood Group
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Acute Respiratory Failure-III

