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Updated: Feb 24, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
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Sensitive and Selective "Turn-On" Chemodosimetric Probes for Fe3+ Based on a Skeleton of 2-Hydroxy-1-Naphthaldehyde
Ghulam Shabir1, Aamer Saeed2, Pervaiz Ali Channar1
1Department of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Abstract:
A naked-eye colored chemodosimeteric probes 4a-f, based on Schiff-azo dye conjugates were synthesized and characterized. All compounds 4a-f exhibited excellent selectivity and high sensitivity in absorbance toward detection of Fe3+ in alcoholic solutions under neutral pH conditions. The detection limit of the probe was shown to be up to 0.05 ppm. A simple paper test strip system for the rapid monitoring of Fe3+ was developed, indicating their convenient use in environmental samples. Electrochemical analysis of metal free conjugates and iron chelated probes confirmed the chelation of ligands. Graphical Abstract.
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