Related Experiment Video
Updated: Feb 24, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Differentiating between cold agglutinins and rouleaux: a case series of seven patients
Michele Heath1, Julie Walker1, Atilio Barbeito1,2
11 Durham VA Medical Center, Durham, North Carolina, 508 Fulton Street, Durham, NC, 27705, USA.
Abstract:
We present a case series of seven patients with suspected cold agglutinin antibodies, discovered after initiation of bypass. Laboratory analysis of blood samples intraoperatively determined the cause of the aggregation to be rouleaux formation in three of the patients and cold agglutinins in the other four.
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