[Clinical Features and Prognosis of t(8;21) AML Patients in China: A Multicenter Retrospective Study]

To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China.

The factors affecting prognosis of patients with t(8;21) AML were investigated by using univariate and multivariate COX regression.

The immune type of t(8;21) AML patients was mainly with HLA-DR⁺, CD117⁺, CD34⁺, MPO⁺, CD38⁺, CD13⁺ and CD33⁺ (>95%), part of them with CD19⁺ and CD56⁺; the most common accompanied mutation of t(8;21) AML patients was C-KIT mutation (37.8%); in addition to t(8;21) ectopic, the most common chromosomal abnormality was sex chromosome deletions (38.9%). The univariate analysis revealed a significant survival superiority of OS and PFS in t(8;21) AML patients of WBC≤3.5×10⁹/L without C-KIT mutation, the newly diagnosed ones achieved HSCT(P<0.05), only survival superiority on OS in t(8;21) AML patients with extramedullary infiltration and CD19 positive; the results of multivariate analysis showed a significant survival superiority on OS and PFS in t(8;21) AML patients with WBC≤3.5×10⁹/L(P<0.05).

The clinical features of t(8;21) AML patients in China are similar to those in other countries, WBC≤3.5×10⁹/L is a good prognostic factor while the C-KIT mutation is a poor one in t(8;21) AML patients.