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Updated: Feb 24, 2026

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
18.8K
[Self-tanning and sunless tanning products]
1109, route de Limonest, 69380 Lissieu, France.
Annales De Dermatologie Et De Venereologie
|August 22, 2017
Summary
Dihydroxyacetone (DHA) in self-tanners creates a temporary tan via the Maillard reaction with skin amino acids. The resulting melanoidin pigments offer safe, semi-permanent coloration until skin shedding.
Area of Science:
- Cosmetic science
- Dermatology
- Organic chemistry
Background:
- Self-tanning products aim to mimic natural tans without UV exposure.
- Dihydroxyacetone (DHA) is the primary active ingredient in most sunless tanning formulations.
- Alternative active ingredients include erythrulose and tyrosine derivatives.
Purpose of the Study:
- To explain the chemical mechanism behind DHA-induced skin coloration.
- To describe the properties and limitations of current self-tanning technologies.
Main Methods:
- The study focuses on the chemical interactions between DHA and skin components.
- Explanation of the Maillard reaction as the key chemical process.
- Identification of the resulting pigments and their location within the skin.
Main Results:
- DHA reacts with skin amino acids via the Maillard reaction to form melanoidins.
- These melanoidin pigments are deposited in the stratum corneum, providing a semi-permanent color.
- The coloration is well-tolerated by the skin and lasts until natural skin cell turnover.
Conclusions:
- DHA is the most effective ingredient for achieving lasting, natural-looking sunless tans.
- The Maillard reaction provides a safe and semi-permanent method for skin coloration.
- Despite formulation and storage challenges, DHA-based products offer superior results compared to alternatives.
Keywords:
AutobronzantsDHADihydroxyacetoneDihydroxyacétoneErythruloseMelanoidinsMelanotanMélanotanMélanoïdinesSelf-tanning productsTroxerutinTroxérutineTyrosineÉrythruloseMore Related Videos
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