Related Experiment Video
Updated: Feb 24, 2026
Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids
Yunpeng Liu1,2, Liuqing Wen2, Lei Li2
1National Glycoengineering Research Center, Shandong Provincial Key Lab of Carbohydrate Chemistry, and State Key Lab of Microbial Technology, Shandong University, Jinan, Shandong 250100, People's Republic of China.
Abstract:
A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl N-phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.
