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Beta-adrenergic bronchodilators.
Respiration; International Review of Thoracic Diseases
|January 1, 1986
Summary
Long-acting beta 2-selective agonists are key for reversible airway obstruction. Aerosol therapy offers effective bronchodilation with fewer side effects compared to oral or parenteral routes.
Area of Science:
- Pharmacology
- Respiratory Medicine
Background:
- Long-acting beta 2-selective agonists are a primary treatment for reversible airway obstruction.
- These modern agents are effective via multiple administration routes, managing and preventing bronchospasm.
Purpose of the Study:
- To compare the efficacy and side effect profiles of different administration routes for long-acting beta 2-selective agonists.
Main Methods:
- Review of available data on aerosol, oral, and parenteral administration of long-acting beta 2-selective agonists.
- Pharmacologic profile comparison of common agents like albuterol, terbutaline, and fenoterol.
Main Results:
- Aerosol therapy demonstrates comparable bronchodilation to oral and parenteral routes.
- Aerosol administration is associated with significantly fewer adverse effects.
Conclusions:
- Aerosol delivery is a preferred method for administering long-acting beta 2-selective agonists due to its favorable efficacy and safety profile.
- The choice between specific agents like albuterol, terbutaline, and fenoterol may be less critical than the route of administration.