Related Experiment Video
Updated: Feb 24, 2026
05:25
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
Published on: December 29, 2021
3.0K
Cannabinoids as Anticancer Drugs
1Institute of Pharmacology and Toxicology, Rostock University Medical Center, Rostock, Germany.
Advances in Pharmacology (San Diego, Calif.)
|August 23, 2017
Summary
Cannabinoids show promise in cancer treatment by inhibiting tumor growth and spread through various mechanisms. While some cannabinoids have side effects, others like cannabidiol offer a good safety profile for potential cancer therapies.
Area of Science:
- Pharmacology
- Oncology
- Endocannabinoid System Research
Background:
- The endocannabinoid system is a key target for treating various diseases.
- Cannabinoids are being investigated for systemic cancer treatment beyond palliative care.
Purpose of the Study:
- To review the role of the endocannabinoid system and cannabinoids in tumor progression.
- To summarize the potential of cannabinoid compounds as anticancer agents.
Main Methods:
- Review of in vitro studies and rodent models investigating cannabinoid effects on cancer.
- Analysis of mechanisms underlying cannabinoid-mediated anti-tumor activity.
Main Results:
- Cannabinoids inhibit tumor growth, invasion, and angiogenesis.
- Mechanisms include apoptosis, autophagy, cell cycle arrest, and immune surveillance enhancement.
- Non-psychoactive cannabinoids like cannabidiol show anticancer properties with a good safety profile.
Conclusions:
- Cannabinoid compounds may offer significant advantages for cancer patients.
- Further research is needed to translate findings from preclinical studies to clinical applications.
- The endocannabinoid system presents a promising therapeutic target in oncology.
Keywords:
CancerCannabinoid receptorsCannabinoidsEndocannabinoidsMetastasisTumor angiogenesisTumor cell invasionMore Related Videos
03:43Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
585
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.9K
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
838
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
838
02:34Inhibition of Cdk Activity
6.1K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
986
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
986
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
01:15Drugs that Stabilize Microtubules
2.8K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.8K
02:18Cancer
54.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.8K