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Published on: February 26, 2013
Risk of stroke in congestive heart failure with and without atrial fibrillation
Si-Hyuck Kang1, Joonghee Kim2, Jin Joo Park1
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.
Insights
Patients with congestive heart failure (CHF) face a higher risk of stroke and thromboembolism. The CHA2DS2-VASc score helps identify stroke risk in CHF patients, similar to those with atrial fibrillation (AF).
Area of Science:
- Cardiology
- Neurology
- Public Health
Background:
- Congestive heart failure (CHF) is a known risk factor for ischemic stroke.
- This study compares stroke and thromboembolism risk in CHF patients versus the general population and atrial fibrillation (AF) patients.
Purpose of the Study:
- To estimate the risk of stroke and thromboembolism in patients with CHF.
- To compare stroke risk between CHF patients, AF patients, and the general population.
- To evaluate the utility of the CHA2DS2-VASc scoring system in stratifying stroke risk for CHF patients.
Main Methods:
- Utilized data from the National Health Insurance Corporation sample cohort (2003-2012).
- Classified patients into control, CHF, AF, and CHF plus AF groups.
- Analyzed annualized stroke risk and assessed the discriminatory value of the CHA2DS2-VASc score.
Main Results:
- CHF patients exhibited a significantly increased risk of ischemic stroke compared to controls.
- Annualized stroke risk was 2.00% for CHF, 2.27% for AF, and 2.87% for CHF plus AF patients.
- The CHA2DS2-VASc score demonstrated moderate discriminatory value for stroke risk in both CHF and AF patients, identifying low-risk individuals.
Conclusions:
- Congestive heart failure patients are at elevated risk for ischemic stroke and thromboembolism.
- The CHA2DS2-VASc scoring system can aid in stratifying individual stroke risk for CHF patients.
- Effective stroke prevention strategies are crucial for managing CHF complications.
Background:
Heart failure has been associated with an increased risk for ischemic stroke. This study estimated the risk of stroke and thromboembolism for patients with congestive heart failure (CHF) in the context of the general population, especially compared to those with atrial fibrillation (AF).
Methods:
Data of patients discharged alive from 2003 to 2012 were extracted from the National Health Insurance Corporation sample cohort. Subjects were classified into control (n=90,277), CHF (n=4533), AF (n=1187), and CHF plus AF (n=1213) groups.
Results:
CHF was associated with an increased risk for ischemic stroke, which was significant after various adjustment models. Annualized stroke risk was 0.54 (0.52-0.57) per 100 person-years for the control group, 2.00 (1.79-2.21) for the CHF group, 2.27 (1.84-2.69) for the AF group, and 2.87 (2.38-3.36) for the CHF plus AF group. The CHA2DS2-VASc scoring schema had a moderate discriminatory value for stroke risk in patients with CHF as well as in AF. The risk of stroke for the CHF group was comparable to that of the AF group when stratified according to the CHA2DS2-VASc scores. Those with CHA2DS2-VASc score of 0 or 1 were at low risk for stroke for both CHF and AF.
Conclusion:
Patients with CHF are at increased risk for ischemic stroke and thromboembolism. This study showed that the CHA2DS2-VASc schema can help stratify stroke risk for individual CHF patients. Stroke is a frequent complication among patients with CHF; therefore, safe and effective strategies to prevent stroke are needed.
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