Insulin Neuritis and Effect of Pregabalin

Area of Science:

• Endocrinology
• Neurology
• Metabolic Disorders

Background:

• Insulin neuritis (IN) is a rare, painful neuropathy associated with diabetes mellitus.
• It typically arises in patients with poorly controlled blood sugar initiating insulin therapy, causing rapid normalization of glucose levels.
• The exact cause of IN remains unclear, though it presents with severe burning pain, weight loss, and mood disturbances.

Observation:

• This report details two cases of patients experiencing acute, severe neuropathic pain following the commencement of insulin therapy for uncontrolled diabetes mellitus.
• Both patients exhibited classic clinical manifestations consistent with insulin neuritis.

Findings:

• Insulin neuritis presents as excruciating, generalized burning pain.
• The condition is characterized by significant weight loss and associated mood issues.
• Diagnosis is primarily clinical, based on patient history and symptoms.

Implications:

• Insulin neuritis is a self-limiting condition that typically resolves on its own.
• Prompt diagnosis and management, including pain management and temporary insulin cessation, are crucial.
• Most cases do not necessitate extensive diagnostic work-up and improve spontaneously.