Related Experiment Video

Updated: Feb 24, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.4K

Gas Reflux in Children with Normal Acid Exposure of the Oesofagus

Felicia Galos1, Catalin Boboc2, Mihaela Balgradean1

  • 1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "Marie Curie" Emergency Children's Hospital Bucharest, Romania.

Maedica
|August 23, 2017
PubMed

Insights

Non-erosive gastroesophageal reflux disease (NERD) can present with varied symptoms in children. A novel diagnostic approach combining pH-metry, multichannel intraluminal impedance, and a glucose respiratory breath test accurately identified gas reflux contributing to symptoms.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Diagnostic Medicine

Background:

  • Non-erosive gastroesophageal reflux disease (NERD) presents with diverse clinical manifestations, influenced by age and individual factors.
  • Weakly acidic reflux and gas within refluxate are implicated in NERD symptom development.
  • Pediatric NERD diagnosis can be challenging due to heterogeneous presentations.

Purpose of the Study:

  • To present a pediatric case of recurrent paroxysmal manifestations suggestive of NERD.
  • To evaluate a combined diagnostic technique for identifying gas reflux in NERD.
  • To establish a link between gas reflux and clinical symptoms in a pediatric patient.

Main Methods:

  • Case report of a 3-year-old child with recurrent paroxysmal symptoms.
  • Utilized pH-metry combined with multichannel intraluminal impedance (MII).
  • Incorporated a glucose respiratory breath test (GRBT) for gas reflux assessment.

Main Results:

  • The combined diagnostic approach successfully confirmed NERD.
  • Positive diagnosis was achieved through pH-metry, MII, and GRBT.
  • The study established a correlation between gas reflux and the patient's reported symptoms.

Conclusions:

  • The integrated diagnostic method is effective for diagnosing NERD in children.
  • Gas reflux plays a significant role in the symptomatology of pediatric NERD.
  • This approach offers valuable insights into the pathogenesis of NERD.

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.8K
Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver08:25

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver

Published on: August 27, 2021

3.0K

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.8K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.0K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.3K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
997
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
998
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
738