[Multiple endocrine neoplasia (MEN)--Wermer and Sipple syndrome]

The illness-process of four patients, two with MEN I (Wermer syndrome) and two with MEN IIa (Sipple syndrome) is described and the therapeutical proceeding explained. The fundamental principle of therapy is the extirpation of hormone producing tumors, in the course of which MEN requires a special sequence in surgical proceeding. Although curative therapy was not possible in all cases, all four patients are still alive. The period of observance surveyed amounts from one year up to eleven years. The importance of family screening is shown in the fact that in two families more sick people were to be found.