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Updated: Feb 24, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)-H and C(sp3)-H Bonds
Qun Li1, Weipeng Hu1, Renjian Hu1
1Institute of Chemistry & BioMedical Sciences, Nanjing University , Nanjing, 210023, China.
Abstract:
Catalytic oxidative cross-dehydrogenative coupling between unactivated C(sp2)-H and C(sp3)-H bonds is achieved by the cobalt-catalyzed o-alkylation reaction of aromatic carboxamides containing (pyridin-2-yl)isopropyl amine (PIP-NH2) as a N,N-bidentate directing group. Many different C(sp3)-H bonds in alkanes, toluene derivatives and even in the α-position of ethers and thioethers can be used as coupling partners. This method has a broad substrate scope and the tolerance of various functional groups.
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