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Updated: Feb 24, 2026
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Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
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Recurrent glomerular disease after kidney transplantation.
Christopher D Blosser1, Roy D Bloom
1aDepartment of Medicine, Division of Nephrology, University of Washington, Washington bDepartment of Medicine, Renal Division, University of Pennsylvania cDepartment of Medicine, Penn Transplant Institute, Pennsylvania, USA.
Current Opinion in Nephrology and Hypertension
|August 24, 2017
Summary
Recurrent glomerular disease is a major cause of kidney transplant failure. New treatments like rituximab and eculizumab show promise for specific conditions, improving long-term graft survival.
Area of Science:
- Nephrology
- Transplantation Immunology
- Glomerular Diseases
Background:
- Recurrent glomerular disease is a growing concern for kidney transplant longevity.
- Understanding its risks and pathogenesis is crucial for improving patient outcomes.
Purpose of the Study:
- To review the current understanding of recurrent glomerular diseases after kidney transplantation.
- To highlight recent advances in diagnosis and treatment strategies.
Main Methods:
- Review of observational studies on recurrent glomerular diseases.
- Analysis of emerging therapeutic evidence for specific conditions.
Main Results:
- Rates of recurrent glomerular diseases have not significantly improved.
- Rituximab shows efficacy in recurrent primary membranous nephropathy and FSGS.
- Eculizumab is effective for C3 glomerulopathy and atypical hemolytic uremic syndrome.
Conclusions:
- Kidney transplantation remains the best option for advanced CKD due to glomerular disease.
- Accurate pre-transplant diagnosis and post-transplant surveillance are vital.
- Development of novel biomarkers and therapies is needed.
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