Related Experiment Video

Updated: Feb 24, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.3K

Fighting Cancer with Mathematics and Viruses

Daniel N Santiago1,2, Johannes P W Heidbuechel3, Wendy M Kandell4,5

  • 1Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Daniel.Santiago@moffitt.org.

Viruses
|August 24, 2017
PubMed

Insights

Oncolytic virotherapy uses viruses to target cancer cells, showing promise in clinical trials. Mathematical modeling can help optimize these treatments by predicting effective strategies for individual patients.

Area of Science:

  • Oncology
  • Virology
  • Computational Biology

Background:

  • Oncolytic virotherapy has advanced to clinical applications for cancer treatment.
  • Oncolytic agents selectively replicate in tumor cells, causing lysis and stimulating antitumor immune responses.
  • Novel agents and combination therapies are under evaluation, necessitating personalized treatment strategies.

Purpose of the Study:

  • To review current developments in oncolytic virotherapy and mathematical modeling.
  • To discuss the integration of mathematical modeling into biological and clinical experimentation for cancer therapy.
  • To propose a synergistic approach combining oncolytic virotherapy and mathematical modeling.

Main Methods:

  • Review of current research in oncolytic virotherapy.
  • Analysis of mathematical modeling approaches in cancer therapy.
  • Discussion of integrating experimental and clinical data with computational models.

Main Results:

  • Oncolytic virotherapy demonstrates multifaceted antitumor effects, including immune stimulation and vascular disruption.
  • Mathematical models can generate hypotheses and predict optimal treatment protocols by incorporating complex biological parameters.
  • Integration of modeling enhances understanding of oncolytic virotherapy mechanisms.

Conclusions:

  • Combining oncolytic virotherapy with mathematical modeling can improve preclinical development and therapeutic efficacy.
  • Personalized treatment strategies are crucial for optimizing oncolytic virotherapy outcomes.
  • A combined research approach is proposed to advance cancer treatment.
Keywords:
cancercombination therapyimmune systemimmunotherapymathematical modeloncolytic virotherapy

More Related Videos

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.8K
Modeling Chemotherapy Resistant Leukemia In Vitro08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.6K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.5K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
793
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.8K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K