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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Feb 24, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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Long-term endothelial dysfunction after trans-radial catheterization: A meta-analytic approach.

Alexios S Antonopoulos1, George Latsios1, Evangelos Oikonomou1

  • 11st Cardiology Department, Hippokration Hospital, University of Athens Medical School, Athens, Greece.

Journal of Cardiac Surgery
|August 24, 2017
PubMed
Summary

Transradial catheterization impairs radial artery endothelial function, potentially limiting its use in coronary artery bypass graft surgery. This dysfunction persists long-term, with male gender and time associated with less impairment.

Keywords:
coronary angiographycoronary catheterizationendothelial functionendotheliumflow-mediated dilationradial arterytransradial

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Vascular Surgery

Background:

  • Transradial access is common for cardiac catheterization.
  • Persistent endothelial dysfunction of the radial artery (RA) post-procedure may hinder its use as a graft in coronary artery bypass graft (CABG) surgery.

Purpose of the Study:

  • To investigate the long-term effects of transradial coronary catheterization on RA endothelial function.
  • To determine if RA endothelial function recovers after the procedure.

Main Methods:

  • Systematic review and meta-analysis of 12 studies (490 patients) published up to April 2017.
  • Assessed RA endothelial function (dependent and independent responses) at least one month post-catheterization.
  • Used random effects model and meta-regression to analyze data and explore predictors of dysfunction.

Main Results:

  • Significant reduction in endothelium-dependent RA response post-catheterization (SMD = -0.53).
  • Marginal, non-significant reduction in endothelium-independent response.
  • Controlled studies confirmed significant endothelial dysfunction (SMD = -6.26).
  • Male gender and longer time post-catheterization were associated with less RA dysfunction.

Conclusions:

  • Transradial catheterization impairs endothelium-dependent vasodilatory properties of the RA.
  • This dysfunction is persistent and does not recover even months after the procedure.
  • Impaired vasomotor function of cannulated RAs may limit their future use as arterial grafts in CABG surgery.