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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Is Staphylococcus lugdunensis Significant in Clinical Samples?

Xavier Argemi1,2, Yves Hansmann3,2, Philippe Riegel2

  • 1Hôpitaux Universitaires, Maladies Infectieuses et Tropicales, Strasbourg, France xavier_argemi@hotmail.com.

Journal of Clinical Microbiology
|August 25, 2017
PubMed
Summary

Coagulase-negative staphylococci are significant opportunistic pathogens, especially in hospitals. Staphylococcus lugdunensis is increasingly recognized for causing severe infections due to its virulence factors.

Keywords:
Staphylococcus lugdunensisbiofilmendocarditisosteoarticular infectionsproteasevirulence

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Science

Background:

  • Coagulase-negative staphylococci (CoNS) are a growing concern in healthcare settings.
  • These bacteria frequently act as opportunistic pathogens, causing infections in vulnerable patients.
  • Certain CoNS species, like Staphylococcus lugdunensis, exhibit enhanced pathogenicity.

Purpose of the Study:

  • To highlight the emerging role of Staphylococcus lugdunensis as a significant pathogen.
  • To discuss the virulence factors contributing to severe infections caused by S. lugdunensis.
  • To inform clinicians and microbiologists about the clinical relevance of S. lugdunensis.

Main Methods:

  • Review of clinical data implicating S. lugdunensis in severe infections.
  • Analysis of in vitro studies identifying putative virulence factors.
  • Microbiological assessment of S. lugdunensis in clinical samples.

Main Results:

  • Staphylococcus lugdunensis is associated with severe osteoarticular infections, foreign-body-associated infections, bacteremia, and endocarditis.
  • In vitro studies reveal key virulence factors including adhesion factors, biofilm production, and proteolytic enzymes.
  • These factors provide a molecular basis for the observed clinical manifestations.

Conclusions:

  • Staphylococcus lugdunensis possesses significant pathogenic potential beyond typical CoNS.
  • Understanding its virulence factors is crucial for effective clinical management.
  • Clinicians and microbiologists should consider S. lugdunensis a more formidable pathogen in diagnostic and therapeutic contexts.