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From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
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Looking Back, Looking Forward at Halogen Bonding in Drug Discovery.
Lois Mendez1, Gabriela Henriquez2, Suman Sirimulla3
1Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USA. lmendez9@miners.utep.edu.
Molecules (Basel, Switzerland)
|August 25, 2017
Summary
Halogen bonding is revolutionizing drug discovery by enhancing ligand: receptor interactions. This non-covalent interaction offers unique advantages for computational and synthetic approaches in medicinal chemistry.
Area of Science:
- Medicinal Chemistry
- Computational Chemistry
- Structural Biology
Background:
- Halogen bonding is a significant non-covalent interaction.
- It plays a crucial role in molecular recognition and supramolecular chemistry.
- Recent advances have highlighted its potential in biological systems.
Purpose of the Study:
- To survey the applications of halogen bonding in improving ligand: receptor interactions.
- To illustrate the advantages of halogen atoms in pharmaceutical compounds.
- To explore halogen atoms as both Lewis acids and Lewis bases.
Main Methods:
- Review of classical applications of halogen bonding.
- Analysis of examples in pharmaceutical compounds and biological targets.
- Examination of halogen atoms' roles as Lewis acids and bases.
Main Results:
- Halogen bonding has emerged as a key factor in enhancing ligand: receptor binding.
- This phenomenon has significantly impacted computational drug discovery.
- It has also revitalized synthetic strategies in medicinal chemistry.
Conclusions:
- Halogen bonding offers unique advantages for drug design and development.
- Understanding halogen atoms as Lewis acids and bases is crucial for optimizing molecular interactions.
- This interaction is a powerful tool for advancing medicinal chemistry and drug discovery.
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