Related Experiment Video
Updated: Jul 17, 2026

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41-1 to Maximize
Li-Hong Huang1,2, Meng-Yang Xu1, Hou-Jin Li3
1School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
Abstract:
By feeding various amino acids to the marine fungus Scedosporium apiospermum F41-1, 22 diverse alkaloids, including 14 new compounds, were obtained. Scedapins A-E (1-5) possess a rare skeleton of a pyrazinoquinazolinedione and an imidazoindolone/indolone linked by a tetrahydrofuran ring. Scedapin C (3) is the first example of fumiquinazoline that contains an aminosulfonyl group. Their structures were determined by HRMS, NMR, ECD calculations and X-ray single-crystal diffraction analysis. The biosynthetic pathways of fumiquinazolines 1-18 were proposed. Scedapin C (3) and scequinadoline D (8) displayed significant antiviral activity against hepatitis C.
More Related Videos
06:43Author Spotlight: Enhancing AM Fungi Research with SAP-AS — A Novel Technique for Single-Spore Cultures
Published on: June 14, 2024
07:43Production of Arbuscular Mycorrhizal (AM) Fungal Inoculum and Phenotypic Evaluation of Rice and AM Symbiosis Under Saline Conditions
Published on: March 14, 2025
Related Concept Videos
Bioreactor Controls-III
Antifungal Agents