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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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The long noncoding RNA Malat1: Its physiological and pathophysiological functions.

Xuejing Zhang1, Milton H Hamblin2, Ke-Jie Yin1

  • 1a Pittsburgh Institute of Brain Disorders & Recovery , Department of Neurology , University of Pittsburgh School of Medicine , Pittsburgh , PA USA.

RNA Biology
|August 25, 2017
PubMed
Summary
This summary is machine-generated.

Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is a key long noncoding RNA (lncRNA) involved in various cellular functions and diseases. This review explores Malat1

Keywords:
Long noncoding RNAMalat1cancercardiovascular diseaseneurologic disorderstroke

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Area of Science:

  • Genomics and Molecular Biology
  • Cancer Research

Background:

  • The human genome contains a vast non-coding DNA fraction, producing functional long noncoding RNAs (lncRNAs).
  • Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is a highly expressed and conserved lncRNA.
  • Malat1 is implicated in numerous physiological processes and diverse pathological conditions, particularly cancers.

Purpose of the Study:

  • To review the latest findings on the physiological and pathophysiological roles of Malat1.
  • To discuss the therapeutic potential of Malat1 in various diseases.

Main Methods:

  • Literature review of recent studies on Malat1.
  • Synthesis of information on Malat1's functions and disease associations.

Main Results:

  • Malat1 is crucial for alternative splicing, epigenetic regulation, and cellular differentiation.
  • Malat1 expression is linked to the development and progression of various cancers.
  • Malat1 participates in multiple pathological processes beyond cancer.

Conclusions:

  • Malat1 is a significant lncRNA with diverse biological functions.
  • Understanding Malat1's roles offers potential therapeutic strategies for cancer and other diseases.