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Related Experiment Video

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Functional Gastrointestinal Disorders and Joint Hypermobility: A School-based Study.

Miguel Saps1, Puck J J Blom2, Carlos A Velasco-Benitez3

  • 1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.

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Summary

Joint hypermobility (JH) is equally common in school children with and without functional gastrointestinal disorders (FGIDs). This study found no significant difference in JH prevalence between these groups.

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Rheumatology

Background:

  • Functional gastrointestinal disorders (FGIDs) are common in children.
  • Joint hypermobility (JH) is a condition characterized by excessive joint flexibility.
  • The relationship between FGIDs and JH in pediatric populations requires further investigation.

Purpose of the Study:

  • To determine the prevalence of joint hypermobility (JH) in school-aged children.
  • To compare JH prevalence between children diagnosed with functional gastrointestinal disorders (FGIDs) and healthy controls.
  • To identify factors associated with JH in this cohort.

Main Methods:

  • A cross-sectional study involving 654 school children.
  • FGIDs diagnosed using validated Rome III questionnaires.
  • Children with FGIDs were age- and sex-matched with healthy controls.
  • Joint laxity assessed using the Beighton score (≥4 indicated JH).

Main Results:

  • 148 children (22.6%) were diagnosed with FGIDs.
  • Analysis included 136 children with FGIDs and 136 controls.
  • No significant difference in JH prevalence was observed between the FGID and control groups (OR 1.03, P=0.89).
  • Younger age (OR 2.31) and female sex (OR 2.27) were significantly associated with JH.

Conclusions:

  • Joint hypermobility occurs with similar frequency in school children with and without FGIDs.
  • FGIDs are not associated with an increased prevalence of JH in this population.
  • Younger age and female sex are independent risk factors for JH in school children.