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OPTICAL COHERENCE TOMOGRAPHY ANALYSIS OF OUTER RETINAL TUBULATIONS: Sequential Evolution and Pathophysiological
Rony C Preti1, Andrea Govetto2, Richard Geraldo Aqueta Filho1
1Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.
Retina (Philadelphia, Pa.)
|August 25, 2017
Summary
Outer retinal tubulations (ORTs) frequently appear in eyes with choroidal neovascularization and geographic atrophy. Their formation is linked to specific retinal changes, with open ORTs associated with inner nuclear layer lesions and outer plexiform layer subsidence.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Optical Coherence Tomography
Background:
- Outer retinal tubulations (ORTs) are observed in various retinal conditions.
- Understanding their sequential evolution is crucial for managing related pathologies.
Purpose of the Study:
- To describe the sequential evolution of outer retinal tubulations (ORTs).
- To identify risk factors and associated findings in patients with choroidal neovascularization and/or retinal pigment epithelium atrophy.
Main Methods:
- Retrospective evaluation of spectral domain optical coherence tomography (SD-OCT) scans.
- Analysis of a consecutive cohort of 238 eyes from 119 patients with a mean follow-up of 3 years.
Main Results:
- ORTs were diagnosed in 28.1% of eyes.
- Geographic atrophy and subretinal hyperreflective material were significant risk factors for ORT development.
- ORT formation was associated with microcystic macular lesions and outer plexiform layer subsidence sign.
Conclusions:
- Outer retinal tubulation is a common finding in eyes with choroidal neovascularization and geographic atrophy.
- Open ORTs show specific associations with microcystic macular lesions and outer plexiform layer subsidence.
