The use of temazepam Expidet (FDDF) as a premedicant in children

Related Experiment Video

Updated: Oct 13, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

H G Schroeder

    Acta Psychiatrica Scandinavica. Supplementum
    |January 1, 1986
    PubMed

    Insights

    This study found that a novel oral formulation of temazepam (FDDF) was highly acceptable to children as pre-operative medication. This medication effectively produced a satisfactory demeanor, suggesting its utility in pediatric anesthesia.

    Area of Science:

    • Pediatric Anesthesiology
    • Pharmacology
    • Pre-operative Medication

    Background:

    • Pre-operative anxiety and distress are common in children undergoing surgery.
    • Effective pre-operative medication is crucial for a smooth anesthetic induction.
    • Traditional pre-medicants may have limitations in terms of palatability or onset of action.

    Purpose of the Study:

    • To evaluate the efficacy and acceptability of a novel oral formulation of temazepam (FDDF) as pre-operative medication in pediatric patients.
    • To assess the impact of FDDF on children's demeanor prior to anesthesia.
    • To determine the suitability of FDDF for routine pediatric pre-anesthetic care.

    Main Methods:

    • A cohort of 149 children received temazepam via a novel oral delivery formulation (FDDF) before surgery.
    • Child acceptability of the medication was assessed.
    • Onset of action and the resulting demeanor in the anesthetic room were observed and evaluated.

    Main Results:

    • The novel oral temazepam formulation (FDDF) demonstrated a high degree of acceptability among pediatric patients.
    • The medication exhibited a short duration of onset.
    • A significant percentage of children displayed a satisfactory demeanor in the anesthetic room after administration.

    Conclusions:

    • The novel oral temazepam formulation (FDDF) is a well-accepted and effective pre-operative medication for children.
    • Its rapid onset and ability to induce a calm demeanor make it a valuable option for pediatric pre-anesthetic management.
    • Temazepam FDDF represents a promising addition to the armamentarium for pediatric pre-operative sedation.

    More Related Videos

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings06:59

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

    Published on: November 9, 2016

    Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia04:34

    Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

    Published on: February 17, 2023

    Related Concept Videos

    CNS Depressants: Barbiturates and Benzodiazepines01:14

    CNS Depressants: Barbiturates and Benzodiazepines

    CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
    Parenteral Anesthetics: Overview01:24

    Parenteral Anesthetics: Overview

    Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
    Sedatives and Hypnotics: Overview01:23

    Sedatives and Hypnotics: Overview

    Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
    Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
    Sedatives and Hypnotics Drugs: Barbiturates01:20

    Sedatives and Hypnotics Drugs: Barbiturates

    Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A key...
    Sedatives and Hypnotics Drugs: Benzodiazepines01:19

    Sedatives and Hypnotics Drugs: Benzodiazepines

    Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
    Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
    Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

    Sedatives and Hypnotics Drugs: Miscellaneous Agents

    Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
    Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...