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Impact of spontaneous intracerebral hemorrhage on cognitive functioning: An update
M Planton1, N Raposo1, L Danet1
1Department of Neurology, Toulouse University Hospital, place Dr-Baylac, pavillon Baudot, 31024 Toulouse cedex 3, France; Toulouse NeuroImaging Centre, université de Toulouse, Inserm, UPS, 31000 Toulouse, France.
Insights
Intracerebral hemorrhage (ICH) survivors face high risks of cognitive disorders and dementia. Understanding ICH
Area of Science:
- Neurology
- Neuroscience
- Stroke Research
Background:
- Intracerebral hemorrhage (ICH) causes 15% of strokes and 50% of stroke mortality.
- ICH survivors have a high risk of negative outcomes, including cognitive impairment and dementia.
- Existing research on stroke-related cognitive decline primarily focuses on ischemic stroke, leaving ICH understudied.
Purpose of the Study:
- To highlight the significant link between intracerebral hemorrhage (ICH) and cognitive impairment.
- To emphasize the under-researched area of vascular cognitive impairment following ICH.
- To underscore the relationship between ICH, dementia, and lesion location's impact on cognitive function.
Main Methods:
- Review of existing literature on intracerebral hemorrhage and cognitive outcomes.
- Analysis of the impact of lesion location on neuropsychological profiles after ICH.
- Examination of the pathophysiology of ICH and its correlation with specific cognitive dysfunctions.
Main Results:
- ICH is strongly associated with increased risk of dementia and cognitive disorders.
- Specific cognitive domains affected include language, memory, executive function, processing speed, and gnosis.
- Lesion location significantly influences the neuropsychological deficits observed post-ICH.
Conclusions:
- Intracerebral hemorrhage is a critical risk factor for vascular cognitive impairment and dementia.
- Further research is needed to understand the specific cognitive patterns and long-term outcomes following ICH.
- Targeted interventions and studies focusing on ICH survivors are essential for improving patient outcomes.
Abstract:
Intracerebral hemorrhage (ICH) accounts for 15% of all strokes and approximately 50% of stroke-related mortality and disability worldwide. Patients who have experienced ICH are at high risk of negative outcome, including stroke and cognitive disorders. Vascular cognitive impairment are frequently seen after brain hemorrhage, yet little is known about them, as most studies have focused on neuropsychological outcome in ischemic stroke survivors, using well-documented acute and chronic cognitive scores. However, recent evidence supports the notion that ICH and dementia are closely related and each increases the risk of the other. The location of the lesion also plays a significant role as regards the neuropsychological profile, while the pathophysiology of ICH can indicate a specific pattern of dysfunction. Several cognitive domains may be affected, such as language, memory, executive function, processing speed and gnosis.

