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Related Experiment Videos

Cotransmission.

G Campbell

    Annual Review of Pharmacology and Toxicology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Cotransmission, the release of multiple neurotransmitters from a single neuron, occurs experimentally. While not proven in normal animals, it

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    Area of Science:

    • Neuroscience
    • Neurobiology
    • Cellular Neuroscience

    Background:

    • Cotransmission involves a single neuron releasing two or more substances to control a target cell during one event.
    • While observed experimentally, cotransmission's occurrence in normal animal function remains unproven, though likely.
    • Numerous instances of coexisting potential transmitters in single neurons suggest widespread cotransmission in the peripheral nervous system.

    Purpose of the Study:

    • To explore the phenomenon of cotransmission and its implications for neuronal communication.
    • To discuss the coexistence of neurotransmitters and its potential role in neuronal signaling.
    • To examine the challenges in classifying neuronal types based on transmitter substances.

    Main Methods:

    • Review of existing experimental data on cotransmission.

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  • Analysis of studies documenting coexisting neurotransmitters within single neurons.
  • Consideration of theoretical roles for coreleased substances.

    • Main Results:

    • Cotransmission is confirmed in experimental settings.
    • Many neuronal transmissions appear to involve a single transmitter, with coreleased substances potentially modulating receptors or acting on other targets.
    • Some colocalized substances may not function in transmission, complicating simple neuronal classifications.

    Conclusions:

    • Classifying neurons solely by transmitter substances is becoming increasingly difficult.
    • Evidence suggests preferred combinations of colocalized substances may characterize specific neuronal innervations.
    • Further research is needed to fully elucidate the functional significance of cotransmission in vivo.