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Drug-induced gastrointestinal disorders.

H L Philpott1,2,3, S Nandurkar1,2, J Lubel1,2

  • 1Department of Gastroenterology, Monash University, Eastern Health, Melbourne, Victoria, Australia.

Frontline Gastroenterology
|August 26, 2017
PubMed
Summary

Drug-induced gastrointestinal disorders can mimic IBD and IBS, leading to misdiagnosis. Understanding adverse drug reactions from common medications like antipsychotics, antidepressants, and metformin is crucial for accurate clinical management.

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Area of Science:

  • Gastroenterology
  • Clinical Pharmacology

Background:

  • Drug-induced gastrointestinal disorders can present symptoms similar to Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).
  • Established knowledge exists for adverse effects of drugs like NSAIDs, but less is understood for antipsychotics, antidepressants, and metformin.
  • Accurate recognition of drug-induced GI issues is vital to avoid unnecessary diagnostic procedures and treatments.

Purpose of the Study:

  • To review and synthesize current information on adverse drug reactions affecting the gastrointestinal system.
  • To provide a clinical context for understanding drug-induced gastrointestinal disorders.
  • To highlight the need for further research into less understood drug classes.

Main Methods:

  • Literature review of recent studies on adverse drug reactions.
Keywords:
Adverse Drug ReactionsClinical Decision MakingColorectal MotilityCrohn'S DiseaseDiarrhoea

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  • Integration of findings into a clinical framework.
  • Focus on commonly prescribed medications with less understood gastrointestinal effects.

    • Main Results:

    • Drug-induced gastrointestinal disorders present a diagnostic challenge due to symptom overlap with IBD and IBS.
    • Antipsychotics, antidepressants, and metformin are among commonly prescribed drugs with potential for significant gastrointestinal adverse effects.
    • Understanding these reactions can guide appropriate patient management and diagnostic pathways.

    Conclusions:

    • Recognition of drug-induced gastrointestinal disorders is essential for effective patient care.
    • Further investigation into the gastrointestinal adverse effects of widely used medications is warranted.
    • This review provides a clinical perspective to aid in the identification and management of these conditions.