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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Key factors involved in obesity development.

Zhiyou Wang1, Daixiu Yuan2, Yehui Duan3,4

  • 1State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China.

Eating and Weight Disorders : EWD
|August 26, 2017
PubMed
Summary
This summary is machine-generated.

Obesity is a chronic disease influenced by factors like adipose tissue, mitochondria, muscle, and gut microbiota. This review explores these links and potential treatments for obesity and related metabolic disorders.

Keywords:
Adipose tissue dysfunctionGut microbiotaMitochondrial dysfunctionMyofibersObesityType 2 diabetes mellitus

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Area of Science:

  • Metabolic disorders
  • Obesity research
  • Chronic disease management

Background:

  • Obesity is a complex chronic disease requiring medical intervention.
  • Key factors implicated include adipose tissue dysfunction, mitochondrial dysfunction, muscle fiber alterations, and gut microbiota changes.
  • These factors are linked to obesity and associated metabolic disorders, particularly type 2 diabetes mellitus.

Purpose of the Study:

  • To review the current understanding of the relationship between various biological factors and obesity development.
  • To summarize potential therapeutic strategies for managing obesity.
  • To provide insights into the multifactorial nature of obesity and its comorbidities.

Main Methods:

  • Narrative review of existing scientific literature.
  • Synthesis of information on adipose tissue, mitochondrial, muscle, and gut microbiota roles in obesity.
  • Identification and summary of current and emerging obesity treatments.

Main Results:

  • Multiple biological systems (adipose tissue, mitochondria, muscle, gut microbiota) are interconnected in obesity pathogenesis.
  • Dysfunction in these systems contributes significantly to metabolic disorders like type 2 diabetes.
  • Evidence supports a range of interventions targeting these factors for obesity management.

Conclusions:

  • Obesity development is multifactorial, involving complex interactions between metabolic and physiological systems.
  • Targeting adipose tissue, mitochondrial, muscle, and gut microbiota offers promising avenues for obesity treatment.
  • Integrated approaches are crucial for effective prevention and management of obesity and its associated health risks.