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Related Experiment Videos

Mast cell mediators and asthma.

M Kaliner

    Chest
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Mast cells and their mediators are key players in asthma. Their involvement is evident in allergic asthma and suggested in exercise-induced and nocturnal asthma.

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    Area of Science:

    • Immunology
    • Pulmonology
    • Cell Biology

    Background:

    • Mast cells are immune cells located in various tissues, including those relevant to respiratory function.
    • These cells release mediators that can influence airway inflammation and function.

    Purpose of the Study:

    • To review the evidence linking mast cells and their mediators to both allergic and non-allergic asthma.
    • To discuss the pathological mechanisms involved in asthma pathogenesis.

    Main Methods:

    • Review of existing scientific literature on mast cells and asthma.
    • Analysis of the role of mast cell degranulation and mediator release in asthma.

    Main Results:

    • Mast cell degranulation upon allergen exposure triggers mediator release in allergic asthma.

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  • Pathological features of asthma are significantly influenced by mast cell-derived mediators.
  • Evidence suggests mast cell involvement in non-allergic asthma forms like exercise-induced and nocturnal asthma.

    • Conclusions:

    • Mast cells and their mediators play a critical role in the pathophysiology of allergic asthma.
    • Further investigation is warranted to fully elucidate the role of mast cells in non-allergic asthma subtypes.