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Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
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Itch induces conditioned place aversion in mice.

Di Mu1, Yan-Gang Sun2

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing, 100049, China.

Neuroscience Letters
|August 27, 2017
PubMed
Summary
This summary is machine-generated.

Itch can cause negative emotional responses in mice, leading to conditioned place aversion (CPA) for weeks. This aversion depends on specific nerve pathways involved in transmitting itch signals.

Keywords:
Conditioned place aversionGRPR(+) neuronsPeripheral sensory inputsResiniferatoxinTRPV1

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pruritus Research

Background:

  • Itch sensation has sensory and emotional aspects.
  • Mechanisms of itch transduction and transmission are well-studied in rodents.
  • The capacity of itch to evoke emotional responses in mice remains unclear.

Purpose of the Study:

  • To investigate whether itch induces emotional responses in mice.
  • To determine the neural pathways involved in itch-induced emotional behavior.

Main Methods:

  • Induction of conditioned place aversion (CPA) using pruritogens in mice.
  • Assessment of CPA duration.
  • Experimental disruption of peripheral sensory fibers expressing TRPV1 (transient receptor potential vanilloid subfamily, member 1).
  • Ablation of spinal itch-specific neurons expressing gastrin-releasing peptide receptor.

Main Results:

  • Pruritogens induced CPA in mice, persisting for at least two weeks.
  • Depletion of TRPV1-expressing peripheral sensory fibers attenuated chloroquine-induced CPA.
  • Ablation of spinal gastrin-releasing peptide receptor-expressing neurons abolished itch-induced CPA.
  • Itch-induced CPA is dependent on peripheral itch signal input and spinal itch circuits.

Conclusions:

  • Itch sensation can elicit a significant emotional response in mice, manifested as CPA.
  • The emotional component of itch in mice relies on the integrity of peripheral itch signaling and specific spinal cord pathways.
  • This study establishes a mouse model for studying the emotional consequences of itch.