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Related Experiment Videos

Phenothiazine-induced oculogyric crisis.

L Skorin, B E Onofrey, J D DeWitt

    Journal of the American Optometric Association
    |April 1, 1987
    PubMed
    Summary

    Phenothiazine medications can cause serious side effects like oculogyric crisis, a type of extrapyramidal symptom. This case highlights the importance of recognizing these drug reactions, especially in children.

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    Area of Science:

    • Pharmacology
    • Neurology
    • Toxicology

    Background:

    • Phenothiazines are widely prescribed antipsychotic medications.
    • Extrapyramidal symptoms (EPS) are known adverse effects of phenothiazine use.
    • Oculogyric crisis is a specific, acute dystonic reaction within the EPS spectrum.

    Observation:

    • A case of oculogyric crisis is presented.
    • The patient experienced involuntary upward deviation of the eyes.
    • This reaction was attributed to phenothiazine administration.

    Findings:

    • Phenothiazine-induced oculogyric crisis is a recognized adverse drug reaction.
    • Understanding phenothiazine pharmacology is crucial for diagnosing and managing EPS.
    • Prompt recognition and management can mitigate patient distress and complications.

    Implications:

    • Highlights the need for vigilance in monitoring patients on phenothiazines for EPS.
    • Informs clinicians about the potential for acute dystonic reactions.
    • Emphasizes the importance of considering drug-induced causes for neurological symptoms, particularly in pediatric populations.

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