Mechanisms contributing to cardiac remodelling
Qing-Qing Wu1,2,3, Yang Xiao1,2,3, Yuan Yuan1,2,3
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Clinical Science (London, England : 1979)
|August 27, 2017
Summary
Pathological cardiac remodelling involves detrimental changes in the heart
Area of Science:
- Cardiovascular biology and pathology
Background:
- Cardiac remodelling is adaptive (physiological) or maladaptive (pathological).
- Pathological cardiac remodelling precedes clinical heart failure (HF).
Purpose of the Study:
- To review the molecular and cellular mechanisms driving pathological cardiac remodelling.
Main Methods:
- Literature review of molecular and cellular responses in pathological cardiac remodelling.
Main Results:
- Pathological remodelling involves fibrosis, inflammation, and cellular dysfunction.
- Key cellular dysfunctions include altered cardiomyocyte interactions, oxidative stress, ER stress, and metabolic impairment.
Conclusions:
- Understanding these molecular and cellular pathways is crucial for developing therapies for heart failure.
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